Teaching and Research Discipline:
Organic Chemistry Synthesis & Physico-Organi Studies Of
Organophosphorus Compound
Total No. Of Publications:

National - 24

Short Summary of Teaching and Research accomplished:

During the last five years, I had been engaged in teaching of Post-graduate classes on topics related to organic chemistry mainly. This included topics like: Reactive intermediates, Rearrangement Reactions, Free Radicals, Vitamins, and Steroids-Hormones and some information related to various drugs etc. During this work, the latest books were consulted, So as to provide up-to-date information regarding the above topics. The students were asked questions regarding teaching of different topics and if they had any problems, these were also solved.

In addition to teaching, research was also being carried out and the area includes the study of mechanisms of reactions of Organic Orthophosphates.The Latter were also synthesized and their stability along with reactivity was checked during Hydrolysis in both aqueous as well as mixed-aqueous media. Most of these studies were performed on C-O-P esters, Followed by extension of this work to the C-N-P containing aryl phosphates. The observation consisted of determining Reactive species, Bond-Fission and Molecularly of the esters of both types, and this information led to the mechanistic aspects of the ester,further ,the research activity is now directed towards the synthesis of aryl phosphoramidates(mixed), so that the products thus obtained show optical activity in them. These are then resolved to obtain individual isomers, which are expected to exhibit specific physiological activity I them.

List of 5 top Publications:

(1) Shashi Kala Pandit and Shashi Prabha (1997), Mechanistic Study of Chloroxylenyl Phosphate Resisting Hydrolysis at Low Temperature ‘Oriental J.Chem..Vol.13, No.2. Pp. 159-164.

(2) Shashi Prabha Mamta Bhaduria (1999),’Synthesis and Reaction Kinetics of a Biologically Active Aryl Phosphoramidate ‘Samyank Journal of Chemistry,. Vol.2, No.2. pp. 31-34.

(3) Shashi Prabha and V.Sahni (1999), Kinetic Study of the Hydrolysis of p-Anisidine Phosphoric Triamide (C-N-P) in Acid Medium, Vol.11, No.1. Pp. 99-104.

(4) L.N.Gupta, R.N.Singh and Shashi Prabha (1999), A Novel Synthetic Route To Perkin’s Dye and Acid-Assisted Nucleophilic Rupture of C-N-P Linkages by Kinetic Means ‘, Oriental J.Chem. Vol.15 (1) 127-32.

(5) Mamta Dwivedi and Shashi Prabha ,(2000), ‘Acid –Catalyzed Hydrolysis of an Exceptionally Basic Phosphorotrimidate, ‘Oriental J.ChemVol.16 ,No.3 pp. 511-515